Endocrine Abstracts

The aim of the study was to determine the effect of high-fat diets and dietary fatty acids composition on nuclear androgen receptors protein levels (AR) in rat ventral prostate epithelial and stroma part.The study was conducted on 30 male Wistar rats with initial body mass 250±10 g, divided into five groups fed four experimental and one reference diets during three weeks. Experimental semi-synthetic, high-fat (20% w/w) diets were as follows: diet A ...

Background: Amiodarone-induced thyrotoxicosis (AIT) is sometimes very difficult to treat. Pulse methylprednisolone in addition to oral steroids appears effective in treatment of AIT, but effects of such treatment may be transient.Presentation of The Case: A 65 year old man was admitted our Department because of drug-resistant AIT. He had a history of atrial fibrillation, treated with amiodarone since 2019, and NSTEMI myo...

Introduction: Immunoglobulin-G4-related disease (IgG4RD) is a multidisciplinary problem due to plasmatic cells infiltration and areas of fibrosis in the affected tissues. In IgG4RD, elevation of serum IgG4 immunoglobulins is present. Clinically, the disease is mainly manifested as: autoimmune pancreatitis, salivary gland involvement, sclerosing cholangitis, lymphadenopathy, lachrymal gland enlargement, retroperitoneal fibrosis or orbital pseudotumor. The simultaneous involveme...

Aim of the study: Estimation of the frequancy of diabetes and prediabetes in patients with adrenal incidentaloma (AI) without hormonal activity.Material and methods: The study comprised patients with AI without hormonal activity, verified by CT. The hormonal function of adrenal glands was determined according to the circadian rhythm of cortisol and/or dexametasone suppression test, ACTH, aldosterone, plasma renin activity, DHEAS, androstenedione, 17hydro...

Introduction: Association between autoimmune thyroid disease (AITD) and other autoimmune disorders is common and known as autoimmune polyglandular syndrome (APS). It may involve hypoparathyoridism with Addison disease (AD) and mucocutaneous candidiasis – APS type I, AD with Diabetes mellitus type 1 (DM1) or AITD- APS type II, AITD associated with other autoimmune diseases (excluding AD): DM1- type IIIa, pernicious anemia- IIIb, or alopecia and/or vitiligo and/or other aut...

Introduction: WHO classification of endocrine tumors defines pheochromocytoma as a tumor arising from chromaffin cells in the adrenal medulla. Almost all pheochromocytomas produce catecholamines. An annual incidence of this tumor in the general population is estimated at 3–8 cases/million/year. 40–50% of patients with pheochromocytoma are characterized by sustained hypertension, a similar percentage – only by paroxysmal hypertension and up to 10% are normotensiv...

Introduction: ACTH-secreting macroadenomas account for about 4–10% of Cushing’s disease and are often resistant to surgical treatment and radiotherapy. The aim of the study was to present diagnostic and therapeutic difficulties in a case of cyclic recurrent ACTH-dependent Cushing’s syndrome due to atypical pituitary adenoma.Case report: 50-year-old man with visceral obesity was referred to hospital because of poor control of diabetes and h...

Introduction: Horner’s syndrome represents a clinical symptom that may result from a variety of lesions both in the central and peripheral nervous system. It is a combination of ipsilateral ptosis, pupillary miosis and anisocoria, enophthalmos and facial anhydrosis induced by disruption of the sympathetic innervation of the eye anywhere along its three-neuron trail. Tumors are the most frequent causes of Horner’s syndrome.Aim: Aim of the study ...

Acromegaly is caused by growth hormone-secreting adenoma in more then 95% cases. Ectopic secretion of GH-RH is a rare cause of acromegaly accounting for less than 1% of all cases. The most frequent source of ectopic GHRH is bronchial carcinoid. Clinical and biochemical findings are similar in both conditions. A distinction of pituitary vs extrapituitary acromegaly is important in planning effective management and both reasons should be considered in the diagnostic process....

Spindle Cell Oncocytoma (SCO) is a neoplasm of the adenohypophysis, often pre-operatively misdiagnosed as pituitary macroadenoma due to its rarity. First described in 2002, 28 cases have been described. It is a benign tumour manifesting in adults with no sex predilection, classified as WHO Grade I. A 71-year-old woman presented with bitemporal hemianopia, secondary hypoadrenalism, hypothyroidism and hypogonadotrophic hypogonadism. Imaging in October 2017 confirmed a 18.0×...